MAGAININ I - Names and Identifiers
MAGAININ I - Physico-chemical Properties
Molecular Formula | C112H177N29O28S
|
Molar Mass | 2409.85 |
Density | 1.268±0.06 g/cm3(Predicted) |
Boling Point | 2396.1±65.0 °C(Predicted) |
Storage Condition | −20°C |
MDL | MFCD00133521 |
In vitro study | Magainin 1 interacts with acidic lipids through electrostatic interactions followed by hydrophobic interactions to form an amphiphilic helix, inducing the leakage. Magainin 1 induces the leakage of calcein specifically out of negatively-charged vesicles. The peptide binds to bovine brain phosphatidylserine sonicated vesicles according to the Langmuir isotherm with a binding constant of 3.8×10 5 M-1 and a binding-site number of 0.10 per lipid molecule. |
MAGAININ I - Risk and Safety
MAGAININ I - Reference Information
biological activity | Magainin 1 (Magainin I) is an antibacterial and amphiphilic peptide isolated from Xenopus laevis skin. Magainin 1 showed antibiotic activity against a variety of Gram-negative and Gram-positive bacteria. |
in vitro study | Magainin 1 interacts with acidic lips through electrostatic interactions followed by hydrophobic interactions to form an amphiphilic helix, inducing the leakage. Magainin 1 induces the leakage of calcein specifically out of negatively-charged vesicles. The peptide binds to bovine brain phosphatidylserine sonicated vesicles according to the Langmuir isotherm with a binding constant of 3.8 × 10 5 M-1 and a binding-site number of 0.10 per lipid molecule. |
Last Update:2024-04-09 20:52:54